Diabetes: is it enough to control blood glucose?
The sensitivity versus specificity trade-off
Mario Marzilli, MD, PhD
Cardiovascular Medicine Division, Cardiothoracic Department, University of Pisa,
Heart Metab. (2015) 68:2-3
- The prevalence of diabetes in adults worldwide was estimated to be 2.8% in 2000 and is expected to grow to 4.4% by the year 2030, with the number of adults with the disease rising from 171 million to 366 million within that time frame. The greatest relative increase will occur in the Middle Eastern Crescent, sub-Saharan Africa, and India. In developing countries, the majority of people with diabetes are relatively young, currently 45-64 years of age, in contrast to the diabetic population in developed countries, where most are at least 65 years of age. This pattern is likely to be accentuated by the year 2030. In association with increasing diabetes prevalence, increasing proportions with cardiovascular disease–related morbidity and mortality will inevitably result. The risk of myocardial infarction (MI) in diabetic patients with no previous MI is similar to nondiabetic patients that have a history of MI. Indeed, whereas the 7-year incidence rate of MI in nondiabetics with a history of MI at baseline is 18.8% (vs 3.5% in nondiabetics with no prior MI; P<0.001), the rate in diabetics with no prior MI is 20.2% (vs 45% in diabetics with prior MI at baseline; P<0.001)...
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